How Esketamine Can Work For Those With Treatment-Resistant Depression

Millions of people around the world unfortunately suffer from some form of depression. There are varying treatments available — though it’s not a guarantee that any of them will fully help someone combat the symptoms of depression itself.

There are also individuals suffering from treatment-resistant depression. Normally, something such as psychological conseling can help with depression symptoms. The same can occur with a prescription of antidepressants. However, one specific treatment — Esketamine (also known as SPRAVATO) — is starting to emerge as perhaps something quite effective for those dealing with treatment-resistant depression.

What is Esketamine?

Essentially, esketamine is a stronger version of ketamine. Some studies indicate that esketamine can reverse depressive traits — and even reduce suicidal tendencies. This is a prescription medicine — and is something that cannot be bought over the counter. It must be secured with the permission of a doctor. Normally, the patient will take Esketamine (SPRAVATO) in the form of a nasal spray. The nasal spray must be used with an antidepressant.

What Does The Treatment Do?

According to some doctors, the nasal spray dosage travels with the use of an ion channel (as opposed to other receptors). Essentially, the chemical properties move much faster down the neuron highway of one’s brain. Some studies have even indicated that esketamine has anti-inflammatory properties. This could further help those with auto-immune diseases that also suffer from severe depression.

Nasal Spray

The process behind the nasal spray treatment is rather straight forward. A full comprehensive check-up will be given to completely study the patient and their tendencies. If deemed a candidate for the treatment, one will expect to use the nasal spray (along with an oral antidepressant).

The actual usage of the nasal spray must take place at a medical facility. It’s expected that the patient will need to account for transportation to and from the appointment. Additionally, health officials are said to monitor the patient for roughly two hours after taking the nasal spray.

Common side effects associated with SPRAVATO include (but are not limited to) anxiety, lack of energy, nausea, vomiting, dissociation, and a reduced sense of touch and sensation.


The cost of SPRAVATO will vary, but is often quite affordable.

Image Source: Med Shadow